Prof. Khalafi-nezhad Directory


 

                                                                                                                                                                                                         

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Ali Khalafinezhad

Professor

Office: A-301 Department of Chemistry

Phone: +98 713 613 7129

Email: khalafi@chem.susc.ac.ir

 

Education and Appointments

 BS: Chemistry Department, College of Science, Shiraz University, Iran, 1976

MSc: Chemistry Department, College of Science, Shiraz University, Iran, 1979

PhD:Chemistry Department, College of Science, Shiraz University, Iran, 1990

 

Research Interests

Nucleoside and Nucleotide& Hetrocyclic Chemistry& Drug Discovery, Synthetic Methodology, Multicomponent reactions, Heterogeneous catalysis

Research Summary

 

  1. Afzali, A.; Firouzabadi, H.; Khalafi-Nezhad, A. “Improved ullman synthesis of diaryl ethers” Synth. Commun. 1983, 13, 335.
  1. Hakimelahi, G. H.; Khalafi-Nezhad, Ali. “N-levulination of guanosine” Helv. Chim. Acta. 1983, 66, 757.
  1.  Hakimelahi, G. H.; Khalafi-Nezhad, A. “the synthesis of (6R*, 7R*)-4-carboxy-3-hydroxy-7-phenylacetamido-2- isooxacephem” Helv. Chim. Acta. 1984, 67, 18.
  1. Hakimelahi, G. H.; Sharghi, H.; Khalafi-Nezhad. “the synthesis and application of novel nitrating agent” Helv. Chim. Acta. 1984, 67, 906.
  1. Hakimelahi, G. H.; Khalafi-Nezhad, A; Sharghi, H.; Jarrahpour, A. A.; Zarrinehzad, M. “high yields selective silylation of ribonucleosides with triisopropylsilyl chloride” Iranian. J. Sci. Tech. 1988, 12, 3.
  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “catalytic effect of tetrabutylammonium flouride in the preparation of secoribo-nucleosides” Helv. Chim. Acta. 1989, 72, 1495.
  1. Hakimelahi, G. H.; Sharghi, H.; Jarrahpour, A. A.; Zarrinehzad, M.; Khalafi-Nezhad, A. “a general method for selective acylation, alkylation, carbonation, silylation, sulfonylation and phosphorylation of a single hydroxyl group in polyhydroxyl compounds” Iranian. J. Sci. Tech. 1989, 13, 1.
  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “the syntheses of 1-[[2-Ammino-1-(hydroxymethyl)ethoxy]methyl] uracil and 1,3-bis(2-haloethoxymethyl)pyrimidi ne” J. Sci. I. R. Iran 1989, 1, 280.
  1. Hakimelahi, G. H.; mohanazadeh, F.; Khalafi-Nezhad, A. “tetra(n-butyl)ammonium fluoride as a navel reagent for the preparation of acyclo-nucleosids. The synthesis of 9-[(2-hyroxyethoxy) methyl] adenine (bitamycin)” J. Med. Sci. I. R. Iran 1989, 3, 57.
  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “attempted synthesis of 5′-deoxy-5′-phosphono-isocytidine. synthesis of phosphonic acid derivatives of acyclo-nucleosides” J. Sci. I. R. Iran 1990, 2, 355.

 

  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “the role of chloromethyl ethers in the formation of N-(7) and N-(9)-alkylated isomers of adenine. synthesis of 2-[9-ethoxymethyl] phosphonate” J. Sci. I. R. Iran 1990, 2, 192.

 

  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “an unambiguous procedure for determinations of N-7, and N-9-alkylated isomers of adenine acyclo-nucleosides” J. Sci. I. R. Iran 1990, 2, 199.

 

  1. Hakimelahi, G. H.; Khalafi-Nezhad, A.; mohanazadeh, F. “tetra(n-butyl)ammonium fluoride as a navel reagent for the preparation of 9-[(2-hyroxyethoxy) methyl] adenine” International J. chem. 1990, 1, 9.

 

  1. Hakimelahi, G. H.; Khalafi-Nezhad, A. “attempted synthesis of quinonemethine derivatives of nocardicin and analogues” J. Sci. I. R. Iran 1990, 2, 103.

 

1996

  1. Mohsenzadeh, S.; Almodarres, A.; Khalafi-Nezhad, A. “effects of genotypes and nitrogen or protein content in sorghum” Research & Reconstruction (Scientific and Educational Quarterly of Jahad Sazandegi) 1996, 3, 60.

1998

 

  1. Khalafi-Nezhad, A.; Fareghi Alamdari, R. “stannous chloride: a reagent for removal of dimethoxytrityl group from 5′-dimethoxytirityl nucleosides” Iranian J. Chem. &Chem. Eng. 1998, 17, 58.

1999

 

  1. Khalafi-Nezhad, A.; Hashemi, A. “efficient synthesis of sodium aryloxymethanesunlfonates using microwave irradiation” J. Chem. Res. 1999, 720.

 

2000

  1. Khalafi-Nezhad, A.; Fareghi Alamdari, R.; Zekri, N. “Efficient and selective protection of alcohol and phenols with triisopropylsilyl chloride/imidazole using microwave irradiation” Tetrahedron 2000, 56, 7503.

2001

 

  1. Khalafi-Nezhad, A.; Hashemi, A. “Knoevanagel condensation of barbituric acid with aromatic aldehydes on basic alumina” Iranian J. Chem. &Chem. Eng. 2001, 20, 9.

 

  1. Khalafi-Nezhad, A.; Fareghi Alamdari, R. “Efficient and Catalytic Deprotection of Triphenylmethyl (Tr) Ethers with Ce(OTf)4″ Tetrahedron 2001, 57, 6805.

 

  1. Amirghofran, Z.; khalafi-Nezhad, A.; Tasdighi, F. “induction of differentiation of U937 leukemia cell line by a new nucleoside analogue, 1-phenoxymethyl-6-azauracil” J. Med. Sci. I. R. Iran 2001, 26, 16.

 

  1. Hakimelahi, G. H.; Ly, T. W.; Yu, S-F.; Zakerinia, M.; Khalafi-Nezhad, A.; Soltani Rad, M. N.; Gorgani, M. N.; Chadegani, A. R.; Mousavi-Movahedi, A. A. “design and synthesis of a cephalosporin-retinoic acid prodrug activated by a monoclonal antibody-β-lactamase conjugate” Bioorg. Med. Chem. 2001, 9, 2139.

 

2002

  1. Khalafi-Nezhad, A.; Fareghi Alamdari, R. “Efficient and Catalytic Deprotection of Triphenylmethyl (Tr) Ethers with Ce(OTf)4″ Iranian. J. Sci. Tech. 2002, 26, 393.

 

  1. Hakimelahi, G. H.; Shia, K-S.; Pasdar, M.; Hakimelahi, S.; Khalafi-Nezhad, A.; Soltani Rad, M. N.; Mei, N-W; Mei, H-C.; Saboury, A. A.; Rezaei-Tavirani, M.; Mousavi-Movahedi, A. A. “design, synthesis and biological evaluation of a cephalosporin monohydroguaiaretic acid prodrug activated by a monoclonal antibody β– lactamase conjugate design, synthesis, and biological evaluation of a cephalosporin–monohydroguaiaretic acid prodrug activated by a monoclonal antibody–lactamase conjugate” Bioorg. Med. Chem. 2002, 101, 2927.

 

 

  1. Hakimelahi, G. H.; Shia, K-S.; Pasdar, M.; Hakimelahi, S.; Mousavi-Movahedi, A. A.; Saboury, A. A.; Khalafi-Nezhad, A.; Soltani Rad, M. N.; Osyetrov, V; Wang, K-P.; Liao, J-H.; Luo, F-T. “design, synthesis, and biological evaluation of a series of β-lactam-based prodrugs” Bioorg. Med. Chem. 2002, 101, 3489.

 

  1. Khalafi-Nezhad, A.; Fareghi Alamdari.; “A Facile Synthesis of 2’,3’ – diazido – 2’,3’ –dideoxy 2’,3’ – Secoadenosine”, Iran. J. Sci. Technol. Trans. A, 2002, 26, 399.

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Hakimelahi, G. H.; Mokhtari, B. “one step synthesis of imidazole and benzimidazole acycloaromatic nucleoside analogs” Tetrahedron 2002, 58, 10341.

 

2003

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Hakimelahi, G. H. “synthesis of polyfunctional hydroxy aromatic ring systems (phloroglucide analogs) under microwave irradiation” Helv. Chim. Acta. 2003, 86, 2396.

 

  1. Khalafi-Nezhad, A.; Mokhtari, B.; Soltani Rad, M. N. “direct preparation of primary amides from carboxylic acids and urea using imidazole under microwave irradiation” Tet. Lett. 2003, 44, 7325.

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Khoshnood, A. “an efficient method for the chemoselective preparation of benzoylated 1,2-diols from epoxides” Synthesis 2003, 2552.

 

  1. Abbaspour, A.; Kamyabi, M. A.; Khalafi-Nezhad, A.; Soltani Rad, M. N. “acidity constants and thermodynamic parameters of some phenol derivatives in methanol-water system using potentiometry and spectrophotometry methods” J. Chem. Eng. Data 2003, 48, 911.

 

  1. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Bahrinajafi, R.; Mohammadi, R.; Farrokhroza, A. A. “synthesis of N-alkylated derivatives of imidazole as antibacterial agents” Bioorg. Med. Chem. Lett. 2003, 13, 2863.

 

2004

 

  1. Abbaspour, A.; Kamyabi, M. A.; Khalafi-Nezhad, A.; Soltani Rad, M. N. “charge transfer complexometric study of ferric ion with 4-chloro-2,6-bis(hydroxymethyl)phenol in a methanol-water system using spectrophotometric and potentiometric methods” J. Chem. Eng. Data 2004, 49, 907.

 

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Khoshnood, A. “microwave–assisted ring opening of epoxides with pyrimidine nucleobases: a rapid entry into C-nucleposide synthesis” Synthesis 2004, 583.

 

  1. Mousavi-Movahedi, A. A.; Safarian, S.; Hakimelahi, G. H.; Ataei, G.; Ajloo, D.; Panjehpour, S.; Riahi, S.; Mousavi, M. F.; Mardanyan, S.; Soltani Rad, M. N.; Khalafi-Nezhad, A.; Sharghi, H.; Moghadamnia, H.; Saboury, A. A. “QSAR analysis for ADA upon interaction with a series of adenine derivatives as inhibitors” Nucleotides & Nucleic Acids 2004, 23, 613.

 

 

  1. Mirzaie, M.; Shad-Del, F.; Khalafi-Nezhad, A.; Soltani Rad, M. N. “the study on therapeutic effect of whole alkaloids of peganum harmala on malignant ovine theileriosis due to theileria hirci” Iran J. Veterinary Res. 2004, 5, 24.

 

  1. Khalafi-Nezhad, A.; Mokhtari, B. “tetrabutylammonium bromide: an efficient media for dimethoxytritylation of the 5’-hydroxyl function of nucleosides” Tet. Lett. 2004, 45, 6737.

 

2005

 

 

  1. Khalafi-Nezhad, A.; Zare, A.; Soltani Rad, M. N.; Mokhtari, B.; Parhami, A. “microwave-assisted michael addition of some pyrimidine and purine nucleobases with α,β-unsaturated esters: a rapid entry into carboacyclic nucleoside synthesis” Synthesis 2005, 419.

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Mohabatkar, H.; Asrari, Z.; Hemmatinejad, B. “design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives” B. Bioorg. Med. Chem. 2005, 13, 1931.

 

 

  1. Khalafi-Nezhad, A.; Parhami, A.; Soltani Rad, M. N.; Zare, A. “effcint method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions” Tet. Lett. 2005, 46, 6879.

2006

 

  1. Abbaspour, A.; Mehrgardi, M. A.; Noori, A.; Kamyabi, M. A.; Khalafi-Nezhad, A.; Soltani Rad, M. N. “speciation of iron (II), iron (III) and full-range PH monitoring using paptode: a simple colorimetric method as and appropriate alternative for optodes” Sensors and Actuators B. 2006, 113, 857.

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Sotani Rad, M. N.; Nejabat, G. R. “microwave-assisted N-arylation of some pyrimidine and purine nucleobases” Can. J. Chem. 2006, 84, 979.

 

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Soltani Rad, M. N. “practical synthesis of some novel unsymmetrical 1,3-dialkylpyrimidine derivatives at room temperature” Arkivok 2006, 12, 161.

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Soltani Rad, M. N.; Nejabat, G. R. “regioselective N-arylation of some pyrimidine and Purine Nucleobases”Synth. Commun. 2006, 36, 3549.

 

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Soltani Rad, M. N.; Nejabat, G. R. “silica supported 2,4,6-trichloro-1,3,5-triazine as an efficient reagent for direct conversion of carboxylic acids to amides under solvent-free conditions” Phosphorus, Sulfur, Silicon and the Related Elements 2006, 182, 657.

2007

 

  1. Imanzadeh, G. H.; Khalafi-Nezhad, A.; Mousavi Zare, A. R.; Zare, A.; Parhami, A. “Michael addition of phthalimide with various α,β-unsaturated esters under solvent-free conditions” J. Iranian Chem. Soc. 2007, 4, 229.

 

  1. Soltani Rad, M. N.; Khalafi-Nezhad, A.; Behrouz, S.; Faghihi, M. A. “a simple one-pot procedure for the direct conversion of alcohols into alkyl nitriles using TsIm” Tet. Lett. 2007, 48, 6779.

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Soltani Rad, M. N.; Nejabat, G. R. “highly regioselective N-alkylation of benzotriazole under solvent-Free conditions” J. Iran Chem. Soc. 2007, 4, 271.

 

  1. Zare, A.; Hasaninejad, A. R.; Khalafi-Nezhad, A.; Mousavi Zare, A. R.; Parhami, A. “a green solventless protocol for michael addition of phthalimide and saccharin to acrylic acid esters in the presence of zinc oxide as a heterogeneous and reusable catalyst” Arkivok 2007, (i), 58.

 

  1. Khalafi-Nezhad, A.; Soltani Rad, M. N.; Mousavi Movahedi, A. A.; Kosari, M. “synthesis of acyclic nucleosides with N-[(benzyloxy)(aryl)methyl] substituents as potential HEPT, EBPU, and TNK-651 analogues” Helv. Chim. Acta. 2007, 90, 730.

 

  1. Soltani Rad, M. N.; Behrouz, S.; Khalafi-Nezhad, A. “a simple one-pot procedure for the direct conversion of alcohols into azides using TsIm” Tet. Lett. 2007, 48, 3445.

 

 

  1. Khalafi-Nezhad, A.; Parhami, A.; Soltani Rad, M. N.; Zolfigol, M. A.; Zare, A. “a catalytic method for chemoselective detritylation of 5′-tritylated nucleosides under mild and heterogeneous conditions using silica sulfuric acid as a recyclable catalyst” Tet. Lett. 2007, 48, 5219.

 

  1. Imanzadeh, G. H.; Zare, A.; Khalafi-Nezhad, A.; Hasaninejad, A. R.; Mousavi Zare, A. R.; Parhami, A. “microwave-assisted michael addition of sulfonamides to -unsaturated esters: a rapid entry to protected B-amino acid synthesis” J. Iranian Chem. Soc. 2007, 4, 467.

 

 

  1. Zare, A.; Hasaninejad, A. R.; Khalafi-Nezhad, A.; Mousavi Zare, A. R.; Parhami, A. “organic reactions in ionic liquids: MgO as efficient and reusable catalyst for the Michael addition of sulfonamides to α,β-unsaturated esters under microwave irradiation” Arkivok 2007, (xii), 105.

 

  1. Oryan, A.; Khalafi-Nezhad, A.; Toloo, N.; Soltani Rad, M. N. “effects of 4-chloro-2,6–bis(2-hydroxyl-benzyl)phenol on healing of skin wounds and growth of bacteria” J. Vet. Med. A. 2007, 54, 585.

 

 

  1. Ali Khalafi-Nezhad, Abdolkarim Zare, Abolfath Parhami, Mohammad Navid Soltani Rad, Gholam Reza Nejabat. Silica-Supported 2,4,6-Trichloro-1,3,5-triazine as an Efficient Reagent for Direct Conversion of Carboxylic Acids to Amides Under Solvent-Free Conditions. Phosphorus, Sulfur, and Silicon, 182:657–666, 2007

 

  1. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Motazedian, M. H.; Eskandari, M. “synthesis of metronidazole derivatives as antigiardisis agents” Daru 2007, 15, 17.

 

 

  1. Zare, A.; Hasaninejad, A. R.; Mousavi Zare, A. R.; Parhami, A.; Sharghi, H.; Khalafi-Nezhad, A. “zinc oxide as a new, highly efficient, green and reusable catalyst for microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters in ionic liquids” Can. J. Chem. 2007, 85, 438.

2008

 

  1. Soltani Rad, M. N.; Behrouz, S.; Faghihi, M. A.; Khalafi-Nezhad, A. “a simple procedure for the esterification of alcohols with sodium carboxylate salts using 1-tosylimidazole (TsIm)” Tet. Lett. 2008, 49, 1115.

 

  1. Soltani Rad, M. N.; Khalafi-Nezhad, A.; Behrouz, S.; Faghihi, M. A.; Zare, A.; Parhami, A. “one-pot synthesis of N-alkyl purine and pyrimidine derivatives from alcohols using TsIm: a rapid entry into carboacyclic nucleoside synthesis” Tetrahedron 2008, 64, 1778.
  2. Zare, A.; Hasaninejad, A. R.; Khalafi-Nezhad, A.; Parhami, A.; Mousavi Zare, A. R. “a solventless protocol for michael addiotion of amides to α,β-unsaturated esters promoted by microwave irradiation” J. Iranian Chem. Soc. 2008, 5, 100.

 

  1. Zare, A.; Hasaninejad, A. R.; Parhami, A.; Mousavi Zare, A. R.; Khalafi-Nezhad, A. “microwave-assisted michael addition of amides to a,b-unsaturated esters under solvent-free conditions” Pol. J. Chem. 2008, 82, 1059.

 

 

  1. Zare, A.; Hasaninejad, A. R.; Beyzavi, M. H.; Parhami, A.; Mousavi Zare, A. R.; Khalafi-Nezhad, A.; Sharghi, H. “zinc oxide-tetrabutylammonium bromide tandem as a highly efficient, green, and reusable catalyst for the Michael addition of pyrimidine and purine nicleobases to α,β-unsaturated esters under solvent-free conditions” Can. J. Chem. 2008, 86, 317.

 

  1. Khalafi-Nezhad, A.; Parhami, A.; Zare, A.; Mousavi Zare, A. R.; Hasaninejad, A. R.; Panahi, F. “trityl chloride as a novel and efficient organic catalyst for room temperature preparation of bis(indolyl)methanes under solvent-free conditions in neutral media” Synthesis 2008, 617.

 

 

  1. Khalafi-Nezhad, A.; Parhami, A.; Zare, A.; Nasrollahi Shirazi, A.; Mousavi Zare, A. R.; Hasaninejad, A. Can. J. Chem. “Triarylmethyl chlorides as novel, efficient, and mild organic catalysts for the synthesis of N-sulfonyl imines under neutral conditions”2008, 86, 456.

 

  1. Khalafi-Nezhad, A.; Zare, A.; Parhami, A.; Hasaninejad, A. R.; Mousavi Zare, A. R. “Quaternary Ammonium Salts as Highly Efficient and Green Alkylating Agents for N-Alkylation of Azaheterocycles under Microwave Irradiation” J. Iran. Chem. Soc., 2008, 5 (suppl. 1), 413.

 

  1. Hasaninejad, A. R.; Zare, A.; Mousavi Zare, A. R.; Parhami, A.; Sharghi, H.; Khalafi-Nezhad, A. “Preparation of N-Sulfonyl Imines from Sulfonamides and Aryl Aldehydes Using Magnesium Oxide as a Heterogeneous and Reusable Catalyst Under Solvent-Free Conditions” Phosphorus, Sulfur, and Silicon. 2008, 173, 2769.

 

 

  1. Zare, A.; Hasaninejad, A. R.; Mousavi Zare, A. R. Khalafi-Nezhad, A.; Parhami, A.; “An Efficient Solventless Method for the Synthesis of N,N-Dialkyl Sulfonamide-Derivatives” J. Iran. Chem. Soc., 2008, 5, 617.

 

  1. Zare, A.; Hasaninejad, A. R.; Khalafi-Nezhad, A.; Sharghi, H.; Mousavi Zare, A. R.; Parhami, A. “Ionic Liquid-Accelerated Synthesis of Some N-Alkyl Derivatives of Phthalimide and Sulfonamides” J. Chilean Chem. Soc., 2008, 53, 1663.

 

 

  1. Hasaninejad, A. R.; Parhami, A.; Zare, A.; Khalafi-Nezhad, A.; Nasrollahi Shirazi, A.; Moosavi Zare, A. R. “Magnesium Sulfate as an Efficient and Very Cheap Reagent for the Preparation of Bis(indolyl)methanes” Pol. J. Chem. 2008, 82, 565.

 

  1. Khalafi-Nezhad, A.; Parhami, A.; Zare, A.; Mousavi Zare, A. R. “Efficient Method for Direct Preparation of Aryl Carboxylates from Carboxylic Acids Using Tosyl Chloride Under Solvent-free Conditions” J. Iran. Chem. Soc. 2008, 5, 413.

 

 

  1. Mahnam, K.; Bahrami, H.; Moosavi-Movahedi, A. K.; Saboury, A. K.; Iranmanesh, M.; Hakimelahi, G. H.; Soltani Rad, M. N.; Khalafi-Nezhad, A. “A Theoretical Investigation of Mechanism of the Adenosine Deaminase Modification: Reaction of Glutamate Residue with Woodward Reagent K” J. Theoretical. Comput. Chem. 2008, 7, 1121.

 

  1. Zare, A.; Hasaninejad, A.; Safinejad, R.; Moosavi-Zare, A. R.; Khalafi-Nezhad, A.; Beyzavi, M. H.; Mirali-Moradi, M. “ Ionic Liquid accelerated Michael addition of pyrimidine and purine Nucleobases to α,β-unsaturated esters : a rapid approach to carboacyclic nucleosides synthesis” Arkivoc, 2008, (xvi), 51-54.

 

 

  1. Zare, A.; Hasaninejad, A.; Mousavi-Zare, A. R.; Beyzavi, M. H.; Khalafi-Nezhad, A.; Pishahang, N.; Parsaee, Z.; Mahdavinasab, P.; Hayati, N.; “KF/Al2O3 as a highly efficient reagent for the synthesis of N-aryl derivatives of pyrimidine and purine nucleobases” Arkivoc, 2008, (xvi), 178-188.

 

  1. Zare, A.; Hasaninejad, A.; Mousavi-Zare, A. R.; Khedri, F.; Rahimi, R.; Khalafi-Nezhad, A.; “Cs2CO3/[bmim]Br as an Efficient, Green, and Reusable Catalytic System for the Synthesis of N-Alkyl Derivatives ofPhthalimide underMild Conditions” Res. Lett Org. Chem. 2008. ID: 419054.

 

 

  1. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Pakshir, K.; Roosta, A.; Baratzadeh, Z. “Design and synthesis of imidazole and benzimidazole derivatives as antifungal agents” Anti-Infective Agents in Medicinal Chemistry 2008, 7 (3), 215.

2009

 

  1. Zare, A.; Hasaninejad, A.; Mousavi-Zare, Abdolalipour-Saretoli, M.; Khedri, F.; Amoozegar, A.; Khalafi-Nezhad, A.; “KF/Al2O3 as an efficient Catalyst for the synthesis of N-Alkylphetalimides” J. Chem. Soc. Pak.; 2009. 31. 309.

 

 

  1. Zare, A.; Hasaninejad, A.; Beyzavi, M. H.; Mousavi-Zare, A. R.; Khalafi-Nezhad, Asadi, F,; Barmaki, L,; Jomhori-Angali, S.; Ghaleh-Gholabi, R.; “KF/Al2O3 as a Highly Efficient, Green, Heterogeneous, and Reusable CatalyticSystem for the Solvent-Free Synthesis of Carboacyclic Nucleosides via MichaelAddition Reaction” Synth. Commun. 2009. 39. 139.

 

  1. Zare, A.; Parhami, A.; Mousavi Zare, A. R.; Hasaninejad, A.; Khalafi-Nezhad, A.; Beyzavi, M. H. “A Catalyst Free Protocol for the Green and Efficient Condensation of Indoles with Aldehydes in Ionic Liquids” Can. J. Chem. 2009, 87, 416.

 

 

  1. Hassaninejad, A.; Zare, A.; Parhami, A.; Mousavi Zare, A. R.; Bargebid, R.; Beyzavi, M. H.; Khalafi-Nezhad, A.; Arghoon, A.; Merajoddin, M.; Moosavi, S. A.; Dara, A.; Shekouhy, M. “Potassium Fluoride as an Efficient and Reusable Reagent for the Synthesis of N,N-Dialkylsulfonamides via Aza Conjugate Addition Reaction Under Microwave Irradiation” Org. Prep. Proced. Int. 2009. 41. 291.

 

  1. Zare, A., Hasaninejad, A., Moosavi-Zare, A.R., Parhami, A., Khalafi-Nezhad, A. “A conversion of carboxylic acids to amides under microwave irradiation” Asian Journal of Chemistry 2009, 21 (2), 1090.

 

 

  1. Rad, M.N.S., Khalafi-Nezhad, A., Behrouz, S. “Design and synthesis of some novel oxiconazole-like carboacyclic nucleoside analogues, as potential chemotherapeutic agents” Helvetica Chimica Acta 2009, 92 (9), 1760.

 

  1. Khabnadideh, S.; Rezaei, Z.; Khalafi-Nezhad, A.; Pakshir, K.; Heiran, M.J.; Shobeiri, H. “Design and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents” Iranian Journal of Pharmaceutical Sciences 2009, 5(1), 31.

 

  1. Soltani Rad,M.N.,Khalafi-ezhad,A.,Asrari,Z.,Behrouz,S.,Amini,Z.,Behrouz,M.”One-Pot Synthesis of Sulfonamides from Primary and Secondary Amine Derived Sulfonate Salts Using Cyanuric Choride” Synthesis 2009, 23, 3983.

 

 

  1. Rad, M. N. S.; Khalafi-Nezhad, A.; Behrouz, S.; Asrari, Z.; Behrouz, M.; Amini, Z. “One-pot synthesis of N-alkyl purin, pyrimidine and azole derivatives from alcohols using Ph3P/CCl4: A rapid rout to carboacyclic nucleoside synthesis” Synthesis 2009, 18, 3067.

 

  1. Zare, A; Hasaninejad, A; Beyzavi, M. H; Moosavi-Zare, A. R; Khalafi-Nezhad, A.; Roshankar, M.; Fiouzi, F;Azad, S.”KF/Al2O3 as an efficient, green, and reusable catalytic system for the solvent-free synthesis of N-alkyl derivatives of sulfonamides via Michael reactions” Phosphorus, Sulfur and Silicon and Related Elements 2009,184 (7), 1702.

 

 

  1. Zare, A.; Moosavi-Zare, A. R.; Hasaninejad, A.; Parhami, A.; Khalafi-Nezhad, A.; Beyzavi, M. H. “Green, Catalyst-Free Protocol for the Efficient Synthesis of N-Sulfonyl Aldimines and Ketimines in Ionic Liquid [Bmim]Br” Synthetic communication 2009, 39 (17), 3156.

2010

 

  1. Abbaspour, A.; Refahi, M.; Khalafi-Nezhad, A.; Soltani Rad, M. N.; Behrouz, S. “A selective and sensitive carbon composite coated platinum electrode for aluminium determination in pharmaceutical and mineral water samples” Analitica Chimica Acta 2010, 662 (1), 76-81.

 

 

  1. Soltani Rad, M. N.; Khalafi-Nezhad, A.; Karimitabar, F.; Behrouz, S. “An Efficient One-Pot Synthesis of Oxime Ethers from Alcohols Using Triphenylphosphine/Carbon Tetrachloride” Synthesis 2010, 10, 1724-1730.

 

  1. Moosavi-Movahedi, A. A.; Sepassi Tehrani, H.; Amanlou, M.; Soltani Rad, M. N.; Hakimelahi, G. H.; Tsai, F.-Y.; Ataie, G.; Saboury, A. A.; Ahmad, F.; Khalafi-Nezhad, A.; Poursasan, N.; Sharifizadeh, A. ” Kinetic and conformational studies of adenosine deaminase upon interaction with oxazepam and lorazepam” Protein & Peptide Letters, 2010, 17, 197-205.

 

  1. Zare, A.; Hasaninejad, A.; Khalafi-Nezhad, A.; Moosavi-Zare, A. R.; Beyzavi, M. H.; Khedri, F.; Asadi, F.; Hayati, N.; Asifi, A. “A Highly Efficient Protocol for the Synthesis of N-Aryl Nucleobases Using Zinc Oxide in Ionic Liquids” J. Iran. Chem. Soc., 2010, Vol. 7, No. 2, 461-469.

 

  1. Zekri, N.; Fareghi Alamdari, R.; Khalafi-Nezhad, A. “Solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides” Bull. Chem. Soc. Ethiop. 2010, 24(2), 299-304.

 

 

  1. Soltani Rad, M. N.; Khalafi-Nezhad, A.; Behrouz S. “Synthesis of Some Novel Hydrazo Carboacyclic Nucleoside Analogues” Beilstein J. Org. Chem., 2010,6, 49.

 

  1. Khazaei, A., Zolfigol, M.A., Moosavi-Zare, A.R., Zare, A.,Parhami, A., Khalafi-Nezhad, A.”Trityl chloride as an efficient organic catalyst for the synthesis of 1-amidoalkyl-2-naphtols in neutral media at room temperature” Aplied Catal. A: Gen., 2010, 386, 179-187.

 

 

  1. Rad, M.N.S., Khalafi-Nezhad, A., Divar, M., Behrouz, S.”Silica sulfuric acid (SSA) as a highly efficient heterogeneous catalyst for persilylation of purine and pyrimidine nucleobases and other N-heterocycles using HMDS” Phosphorus, Sulfur and Silicon and the Related Elements, 2010, 185 (9), 1943-1954.

 

  1. Rad, M.N.S., Khalafi-Nezhad, A., Behrouz, S., Amini, Z., Behrouz, M. “A simple and highly efficient one-pot procedure for the synthesis of amides via beckmann rearrangements using 1-tosylimidazole (TsIm)” Phosphorus, Sulfur and Silicon and the Related Elements,2010, 185(8), 1658-1671.

 

 

  1. Soltani Rad, M.N., Khalafi-Nezhad, A., Asrari, Z., Behrouz, S. “Highly efficient one-pot synthesis of N-acylsulfonamides using cyanuric chloride at room temperature” Synthesis, 2010, (15), art. no. P03510SS, pp. 2599-2603.

 

  1. Rad, M.N.S., Khalafi-Nezhad, A., Behrouz, S., Amini, Z., Behrouz, M. “Simple and highly efficient procedure for conversion of aldoximes to nitriles using N-(p-Toluenesulfonyl) imidazole” Synth. Commun. 2010, 40 (16), pp. 2429-2440.

 

 

  1. Abbaspour, A., Refahi, M., Khalafi-Nezhad, A., Soltani Rad, N., Behrouz, S. “Carbon composite-PVC based membrane coated platinum electrode for chromium determination” Journal of Hazardous Materials, 2010, 184 (1-3), pp. 20-25.

 

  1. Soltani Rad, M.N., Khalafi-Nezhad, A., Babamohammadi, S., Behrouz, S. “Microwave-assisted three-component synthesis of some novel 1-alkyl-1H-indole-2,3-dione 3-(o-alkyloxime) derivatives as potential chemotherapeutic agents” Helvetica Chimica Acta, 2010, 93 (12), pp. 2454-2466.

 

 

  1. A.Abbaspour, E. Mirahmadi, A. Khalafi-nejad, S. Babamohammadi, “A Highly Selective and Sensitive Disposable Carbon Composite PVC-based membrane for determination of lead ion in environmental samples”, J. Hazard. Mater. 2010, 174, 656–661.

2011

 

  1. Ali Khalafi-Nezhad, Abolfath Parhami, Rahele Bargebid, Saghar Molazade, Abdolkarim Zare, Habib Foroughi,  “Silica sulfuric acid as mild and efficient catalyst for the preparation of poly-hydroxyl aromatic compounds under mild and heterogeneous conditions” ; Mol. Divers. 2011, 15, 373-381.

 

  1. Khalafi-Nezhad, A., Panahi, F. “Synthesis of New dihydropyrimido[4,5-b]quinolinetrione derivatives using a four-component coupling reaction” Synthesis, 2011, (6), art. no. Z50410SS, pp. 984-992.

 

 

  1. Nabavizadeh, S.M., Amini, H., Shahsavari, H.R., Namdar, M., Rashidi, M., Kia, R., Hemmateenejad, B., Nekoeinia,M.,Ariafard, A.,Niroomand Hosseini, F., Gharavi, A., Khalafi-Nezhad, A., Sharbati, M. T., Panahi, F.
    “Assembly of cyclometalated platinum(II) complexes via 1,1′- bis(diphenylphosphino)ferrocene ligand: Kinetics and mechanisms ” Organometallics, 2011, 30 (6), pp. 1466-1477.

 

 

  1. Khalafi-Nezhad, A., Panahi, F. “Immobilized palladium nanoparticles on a silica–starch substrate (PNP–SSS): as an efficient heterogeneous catalyst for Heck and copper-free Sonogashira reactions in water” Green Chemistry, Green Chemistry 2011, 13 (9), 2408-2415.
  2. Khalafi-Nezhad, A., Foroughi, H. O., doroodmand, M. M., Panahi, F., “Silica boron–sulfuric acid nanoparticles (SBSANs): preparation, characterization and their catalytic application in the Ritter reaction for the synthesis of amide derivatives” J. Mater. Chem., 2011, 21 (34), 12842-12851.

 

  1. Soltanirad, M.N., Behrouz, S., Nekoei, A.R., Faghih, Z., Khalafi-Nezhad, A.; “Three-component synthesis of some novel N-heterocycle methyl-O-oxime ethers” , Synthesis 2011, 4068-4076.

 

 

  1. Soltani Rad, M.N., Asrari, Z., Behrouz, S., Hakimelahi, G.H., Khalafi-Nezhad, A.; ‘Click synthesis’ of 1H-1,2,3-triazolyl-based oxiconazole (=(1Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[(2,4- dichlorophenyl)methyl]oxime) analogs, Helvetica Chimica Acta 2011 , 94 (12) , pp. 2194-2206.

 

2012

  1. Yousefi, R., Khalafi-Nezhad, A., Soltani Rad, M.N., Behrouz, S., Panahi, F., Esmaili, M., Ghaffari, S.M., Niazi, A., Moosavi-Movahedi, A.A., “Structure-cytotoxicity relationship of a novel series of miconazole-like compounds” Medicinal Chemistry Research, 2012, 21, 1921–1928.

 

  1. Khalafi-Nezhad, A.; Haghighi, S. M.; Purkhosrow, A.; Panahi, F., An Efficient One-Pot Access To Quinazolinone Derivatives Using TiO2-nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation, Synlett, 2012, 23, 920-924.

 

 

  1. A. Parhami, A. Khalafi-Nezhad, S. M. Haghighi, R. Bargebid,A. Zare, A. R. Moosavi-Zare,and M. Nikrooz, Silica supported boric tri-sulfuric anhydride as a novel and efficient catalyst for solvent-free synthesis of coumarins via Pechmann condensation, Arkivoc 2012, 2012 (ix) 111-121.

 

  1. Khazaei, A., Zolfigol, M.A., Moosavi-Zare, A.R., Zare, A., Khojasteh, M., Asgari, Z., Khakyzadeh, V., Khalafi-Nezhad, A. “Organocatalyst trityl chloride efficiently promoted the solvent-free synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]-xanthen-11-ones by in situ formation of carbocationic system in neutral media” Catalysis Communications, 2012, 20 , pp. 54-57.

 

 

  1.  Memarzadeh, R., Panahi, F., Javadpour, S., Khalafi-Nezhad, A., Noh, H.-B., Shim, Y.-B. “The interaction of CO to the Co(salen) complex in to PEDOT:PSS film and sensor application” Bulletin of the Korean Chemical Society, 2012, 33 (4) , pp. 1297-1302.

 

  1. Mohammad Navid Soltani Rad, Somayeh Behrouz, Fatemeh Karimitabar, Ali Khalafi-Nezhad, ‘Click Synthesis’ of Some Novel O-Substituted Oximes Containing 1,2,3-Triazole-1,4-diyl Residues as New Analogs of β-Adrenoceptor Antagonists, Helv. Chim. Acta 95, 491-501 (2012).
  2. Khazaei, A., Rahmati, S., Khalafi-Nezhad, A., Saednia, S. “Selectfluor™ F-TEDA-BF 4 mediated thiocyanation or isothiocyanation of alcohols by in situ generation of [ +SCN] under heterogeneous and neutral conditions” Journal of Fluorine Chemistry, 2012, 137 , pp. 123-125.

 

  1.  Khalafi-Nezhad, A., Mohammadi, S. ” Highly efficient synthesis of novel Morita-Baylis-Hillman adducts from activated ketones using a DABCO-based hydroxy ionic liquid (HIL) as a recyclable catalyst-solvent” Synthesis (Germany), 2012, 44 (11) , pp. 1725-1735.

 

  1.  Zare, A., Merajoddin, M., Abi, F., Moosavi-Zare, A.R., Mokhlesi, M., Zolfigol, M.A., Asgari, Z., Khakyzadeh, V., Hasaninejad, A., Khalafi-Nezhad, A., Parhami, A. ” Trityl chloride (TrCl): Efficient and homogeneous organocatalyst for the solvent-free synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes by in situ formation of carbocationic system” Journal of the Chinese Chemical Society, 2012, 59 (7) , pp. 860-865.

 

 

 

  1. Ali Khalafi-Nezhad, Farhad Panahi “Immobilized palladium nanoparticles on silica-starch substrate (PNP-SSS): As a stable and efficient heterogeneous catalyst for synthesis of p-teraryls using Suzuki reaction” Journal of Organometallic Chemistry, 2012, 717, 141-146.

 

  1.  Ali Khalafi-Nezhad, Samira Sarikhani, Elham Shaikhi Shahidzadeh and Farhad Panahi “L-proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: Regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water” Green Chemistry, 2012, 14, 2876–2884.

 

2013

 

  1. Ali Khalafi-Nezhad, Farhad Panahi, Somayeh Mohammadi, Habib Ollah Foroughi “A green and efficient procedure for one-pot synthesis of xanthenes and acridines using silica boron–sulfuric acid nanoparticles (SBSANs) as a solid Lewis-protic acid, J. IRAN CHEM. SOC., 2013, 10, 189–200.

 

  1.   Ali Khalafi-Nezhad, Farhad Panahi, Bahman Golesorkhi ‘One-pot Synthesis of 7-Thioxo-tetrahydropyrido[2,3-d:6,5-d]dipyrimidine-1,3,9-triones via a Four-Component Coupling Reaction of Aldehydes, Amines, Barbituric Acids and Thiouracil, Helvetica Chimica Acta, 2012, 96, 1155-1162.

 

  1.  Ali Khalafi-Nezhad, Habib Ollah Foroughi, Farhad Panahi “Silica Boron-Sulfuric Acid Nanoparticles (SBSANs): as an Efficient and Reusable Catalyst for Large-Scale Synthesis of α-Amino Nitriles Using Strecker Reaction” Heteroatom Chemistry, 2013, 24,1-8.

 

 

  1.  Reza Yousefi, Mohammad-Mehdi Alavian-Mehr, Fatemeh Mokhtari, Farhad Panahi, Mohammad H. Mehraban, and Ali Khalafi-Nezhad “Pyrimidine-fused heterocycle derivatives as a novel class of inhibitors for α-glucosidase” Journal of Enzyme Inhibition and Medicinal Chemistry, 2013; 28(6): 1228–1235.

 

  1. Ali Khalafi-Nezhad, Masoumeh Divar, Farhad Panahi “Nucleosides as reagents in multicomponent reactions: one-pot synthesis of heterocyclic nucleoside analogues incorporating pyrimidine-fused rings” Tetrahedron Letters 54 (2013) 220–222.

 

 

  1. Ali Khalafi-Nezhad and Somayeh Mohammadi “Highly efficient synthesis of 1- and 5-substituted1H-tetrazoles using chitosan derived magnetic ionic liquid as a recyclable biopolymer-supported catalyst” RSC Advances, 2013, 3, 4362-4371.

 

  1.  Ali Khalafi-Nezhad and Farhad Panahi “Phosphine-functionalized magnetic nanoparticles (PFMN) as a magnetic recyclable phosphorus ligand: preparation of its palladium(II) complex for Heck reaction of chloroarenes” Journal of Organometallic Chemistry, 2013, 741-742 (2013) 7 -14.

 

 

  1.  Ali Khalafi-Nezhad, Saghar Mowlazadeh Haghighi, Farhad Panahi “Nano-TiO2 on Dodecyl Sulfated Silica: As an Efficient Heterogeneous Lewis Acid-Surfactant-Combined Catalyst (HLASC) for Reaction in Aqueous Media” ACS Sustainable Chemistry & Engineering 2013, 1, 1015 − 1023.

 

  1. Ali Khalafi-Nezhad, Elham Shaikhi Shahidzadeh, Samira Sarikhani, Farhad Panahi “A new silica-supported organocatalyst based on L-proline: An efficient heterogeneous catalyst for one-pot synthesis of spiroindolones in water” Journal of Molecular Catalysis A: Chemical, 2013, 379, 1– 8.

 

 

  1. Farhad Panahi; Reza Yousefi; Mohammad Housein Mehraban; Ali Khalafi-Nezhad “Synthesis of New Pyrimidine-Fused Derivatives as Potent and Selective Antidiabetic -Glucosidase Inhibitors” Carbohydrate Research 2013, 380, 81–91.

 

 

  1.  Mohammad Hossein Mehraban; Reza Yousefi; Asghar Taheri-Kafrani; Farhad Panahi; Ali Khalafi-Nezhad “Binding study of novel anti-diabetic pyrimidine fused heterocycles to -lactoglobulin as a carrier protein” Colloids and Surfaces B: Biointerfaces, 2013, 112, 374–379.

 

  1. Ali Khalafi-Nezhad and Somayeh Mohammadi “Magnetic, Acidic, Ionic Liquid-Catalyzed One-Pot Synthesis of Spirooxindoles” ACS Combinatorial Science 2013, 15 (9), pp 512–518.

 

 

  1. H. Ahmadzade Kermani, A. Shockravi, Z. Moosavi-Movahedi, A. Khalafi-Nezhad, S. Behrouz, Fu-Yuan Tsai, G. H. Hakimelahi, A. Seyedarabi, A. A. Moosavi-Movahedi “A surfactant–heme–sulfonyl imidazole system as a nano-artificial enzyme”. J IRAN CHEM SOC (2013) 10:961–968.

 

  1.  Ali Khalafi-Nezhad, Masoumeh Divar, and Farhad Panahi “Synthesis of alpha-Aminonitriles with Benzimidazolic and Theophyllinic Backbones Using the Strecker Reaction”  J. Org. Chem. 2013, 78, 10902 − 10908.

 

2014

 

 

  1. Ali Khalafi-Nezhad and Farhad Panahi. Ruthenium-Catalyzed Synthesis of Benzoxazoles Using Acceptorless Dehydrogenative Coupling Reaction of Primary Alcohols with 2‑Aminophenol under Heterogeneous Conditions. ACS Catal. 2014, 4, 1686−1692.

 

  1. An efficient procedure for the synthesis of phenacyl and benzyl azolium salts using fluorous solvents, J IRAN CHEM SOC (2014) 11:1189–1196.

 

 

  1. Fareghi-Alamdari, Reza; Khalafi-Nezhad, Ali; Zekri, Negar. An Efficient Synthetic Approach to Substituted Trisphenols (Phloroglucide Analogues) Using Tungstosilicic Acid in Water. Synthesis, 2014, 46, 887-892.

 

  1. Somayeh Mohammadi and Ali Khalafi-Nezhad. Chitosan Supported Ionic Liquid: A Recyclable Wet and Dry Catalyst for Direct Conversion of Aldehydes into Nitriles and Amides under mild conditions. RSC Adv., 2014, 4, 13782.

 

 

  1. A. Khalafi-Nezhad, F. Panahi, Size-Controlled Synthesis of Palladium Nanoparticles on a Silica- Cyclodextrin Substrate: A Novel Palladium Catalyst System for the Heck Reaction in Water. ACS Sustainable Chem. Eng. 2014, 2, 1177−1186.
  2. A. Khalafi-Nezhad, M. Nourisefat, and F. Panahi. Me3SiI as a Multifunctional Agent in One-pot Synthesis of 9-(1H-indol-3-yl)-xanthen-4-(9H)-ones using Reaction of O-methyl protected Salicyaldehydes, Indoles and β-Dicarbonyl Compounds Synthesis, 2014, 46, 2071-2078.

 

  1. H. Tavallalia, G. Deilamy_Rada, A. Parhamia, and Ali Khalafi-Nezhad, “A Selective Fluorescent and Colorimetry Competition Assay  for Fluoride Ions in DMSO Media Based on 4_Chloro_2,6_bis  bis(Hydroxymethyl) Phenol “ , Journal of Analytical Chemistry , 2014, Vol. 69, pp. 157–161.

 

  1. M. Nourisefat,   F. Panahi and A. Khalafi-Nezhad. Carbohydrates as reagent in multicomponent reaction: One-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles. Org. Biomol. Chem., 2014,12, 9419-9426.

 

  1. Soltani Rad, M.N., Behrouz, S., Asrari, Z., Khalafi-Nezhad, A. A simple and regioselective one-pot procedure for the direct N-acylation of some purine and pyrimidine nucleobases via carboxylic acids using cyanuric chloride. Monatshefte für Chemie-Chemical Monthly, 2014, Article in press.

 

  1. Magnetic nanoparticles-supported tungstic acid (MNP-TA): As an efficient magnetic recyclable catalyst for one-pot synthesis of spirooxindoles in water, Ali Khalafi-Nezhad, Masoumeh Divar and Farhad Panahi, RSC Adv., 2014, Accepted Manuscript.